发明名称 |
Mutagenized IL 13-based chimeric molecules |
摘要 |
This invention provides mutagenized interleukin 13 molecules that show improved specificity for the restricted (IL4 independent) IL13 receptor and reduced cross-reactivity with the IL4/IL4 shared receptor. The mutagenized IL13 molecules include one or more mutations in a domain that interacts with the 140 kDa hIL4Rbeta or the hIL13Ralpha1 subunit. These mutagenized IL13 molecules provide effective targeting moieties in chimeric molecules (e.g. fusion proteins) that specifically deliver effector molecules (e.g. cytotoxins) to cells overexpressing IL13 receptors (e.g. cancer cells such as gliomas).
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申请公布号 |
US6296843(B1) |
申请公布日期 |
2001.10.02 |
申请号 |
US19980054711 |
申请日期 |
1998.04.03 |
申请人 |
THE PENN STATE RESEARCH FOUNDATION |
发明人 |
DEBINSKI WALDEMAR |
分类号 |
C12N15/09;A61K38/00;A61P35/00;C07K14/21;C07K14/54;C07K19/00;(IPC1-7):A61K45/00;A61K39/00;C07K14/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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