发明名称 |
Selective killing and diagnosis of p53+ neoplastic cells |
摘要 |
Methods and compositions for treating and diagnosing neoplastic disease using viruses are provided. Preferably, mutant adenovirus lacking viral proteins which bind and/or inactivate p53 are administered to a patient having a neoplasm which comprises cells exhibiting p53 and lacking, or substantially devoid of mismatch repair activity. The mutant virus is able to substantially produce a replication phenotype in such neoplastic cells but is substantially unable to produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 function. The preferential generation of a replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype.
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申请公布号 |
US6296845(B1) |
申请公布日期 |
2001.10.02 |
申请号 |
US19980190930 |
申请日期 |
1998.11.12 |
申请人 |
ONYX PHARMACEUTICALS INC. |
发明人 |
SAMPSON-JOHANNES ADAM;KIRN DAVID |
分类号 |
G01N33/50;A61K35/76;A61K48/00;A61P35/00;C12N7/04;C12N15/09;C12Q1/02;C12Q1/68;G01N33/574;(IPC1-7):A61K48/00;C12N15/861;C12N15/63;C12Q1/70 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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