| 摘要 |
PROBLEM TO BE SOLVED: To prepare a powder medicine containing a bitter agent and having excellent taking easiness and provide a method for the production of the medicine. SOLUTION: The powder medicine is produced by mixing a drug-containing sustained-release powder and a placebo powder containing a sweetener. The drug-containing sustained-release powder is produced e.g. by spraying an aqueous solution containing ticlopidine hydrochloride, hardened oil having a melting point of about 60 deg.C, hydrated silicon dioxide, macrogol, hydroxypropyl cellulose and citric acid anhydride, granulating and drying the sprayed particles, heat- treating the product to obtain a drug-containing heat-treated granule and coating the granule with a solution containing a methacrylic acid copolymer. The sweetener-containing placebo powder is produced by spraying an aqueous solution of D-mannitol and hydroxypropyl cellulose and granulating and drying the sprayed particles.
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