Pharmaceutical packing device comprising a hollow plastic body having an improved internal lubricant layer and method of making same

摘要

The pharmaceutical packing device has a hollow plastic body (1) of axial length (I) and a cylindrical portion (7) extending over at least a part of its axial length and an interior silicone lubricant layer (3) provided on an interior surface of the plastic body in the cylindrical portion (7). The lubricant layer (3) provides a sliding surface for a flexible piston (4) slidably mounted in the hollow plastic body, thus forming an injector device. The silicone lubricant layer (3) is made by a method including preparing a mixture of reactive silicone oil and non-reactive silicone oil, applying this mixture to the interior surface at a temperature of at least 40° C. in a single step without activation of the surface to form a preliminary layer and cross-linking the reactive silicone oil in the preliminary layer to form the silicone lubricant layer.