发明名称 |
Stimulus sensitive gel with radioisotope and methods of making |
摘要 |
The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.
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申请公布号 |
US6296831(B1) |
申请公布日期 |
2001.10.02 |
申请号 |
US19980058712 |
申请日期 |
1998.04.10 |
申请人 |
BATTELLE MEMORIAL INSTITUTE |
发明人 |
WELLER RICHARD E.;LIND MICHAEL A.;FISHER DARRELL R.;GUTOWSKA ANNA;CAMPBELL ALLISON A. |
分类号 |
A61K9/10;A61K47/34;A61K51/00;A61K51/06;A61K51/12;A61P35/00;(IPC1-7):A61K51/00;A61M36/14 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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