Plasmidi tyrosiinihydroksylaasigeenin ilmentämiseksi aivoissa

摘要

The present invention relates to gene therapy of neural or non-neural diseases, especially Parkinson's disease. The invention provides a Bovine Papilloma Virus type-1 expression plasmid carrying at lest one therapeutic gene to be transfected in vivo into the cells of a subject. In specific, the invention provides a BPV-1 expression plasmid carrying a tyrosine hydroxylase gene, to be transfected into corpus striatum of a patient for the treatment of Parkinson's disease.