| 摘要 |
The compounds of formula (I) may be used for treating cancer, hyperproliferative cellular disease and for providing an antiangiogenic effect in patients. In formula (I); Q is selected from the group (II) depicted above; G is selected from the group consisting of alkyl, substituted alkyl, optionally substituted aryl, heterocyclo, or the groups (III) depicted above; W is O or NR15; X is O or H, H; Y is selected from the group consisting of O; H, OR16; OR17, OR17; NOR18; H, NOR19; H, NR20R21; H, H; and CHR22; wherein OR17OR17 can be a cyclic ketal; Z1 and Z2 are selected from the group consisting of CH2, O, NR23, S and SO2, wherein only one of Z1 and Z2 is a heteroatom; B1 and B2 are selected from the group consisting of OR24, OCOR25 and OC(=O)NR26R27, and when B1 is H and Y is OH, H they can form a six-membered ring ketal or acetal; D is selected from the group consisting of NR28R29, NR30COR31 and saturated heterocycle; R1, R2, R3, R4, R5, R6, R7, R13, R14, R18, R19, R20, R21, R22, R26 and R27 are selected from the group H, optionally substituted alkyl and aryl; and when R1 and R2 are alkyl can be joined to form a cycloalkyl; and when R3 and R4 are alkyl can be joined to form a cycloalkyl; R9, R10, R16, R17, R24, R25 and R31 are selected from the group H, and optionally substituted alkyl; R8, R11, R12, R28, R30, R32 and R33 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl and heterocyclo; R15, R23 and R29 are selected from the group consisting of H, alkyl, optionally substituted alkyl, optionally substituted aryl, cycloalkyl, heterocyclo, R32C=O, R33SO2, hydroxy, O-alkyl or O-substituted alkyl. |
