Preparation of gatifloxacin and disodium edetate

摘要

Aqueous liquid preparations containing Gatifloxacin ((+/-)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-quinolinecarboxylic acid) or its salt and disodium edetate are provided. The incorporation of disodium edetate into an aqueous liquid preparation containing Gatifloxacin enhances the corneal permeability of Gatifloxacin and prevents crystallization and coloration of Gatifloxacin.