| 摘要 |
A composition for regulating the levels of adenoine or adenosine receptor, reducing hypersensitivity to adenosine, preventing or treating a disease or condition of the heart, liver, lung(s) or brain. The composition consists of a carrier and a epiandrosterone of formula (I) wherein: The broken line represents a single or double bond R is hydrogen or a halogen The H at position 5 is present in alpha or beta configuration or the compound of formula (I) comprises a racemic mixture of both configurations R1 is hydrogen or SO2OM, wherein M is selected from the group consisting of H, Na or a sulphatide of formula (II) or phosphatide of formula (III). Wherein: R2 and R3 which may be the same or different are straight or branched C1-14alkyl or glucuronide of formula (IV), a ubiquinone (CoQn) or formula (V), wherein n=1-12. The composition may be in the form of an inhalable, respirable, intrapulmonary, nasal, topical or transdermal formulation.
|
