发明名称 |
PROCESS FOR THE PREPARATION AND ISOLATION OF ATRACURIUM BESYLATE |
摘要 |
<p>A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N, N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracuriurn besylate is precipitated.</p> |
申请公布号 |
GR3036083(T3) |
申请公布日期 |
2001.09.28 |
申请号 |
GR20010400928T |
申请日期 |
2001.06.19 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
CHAMBERLIN, STEVEN, A.;BHATIA, ASHOK, V.;DAVIS, DEBORAH, A.;DRENGLER, KEITH, A. |
分类号 |
C07D217/20;(IPC1-7):C07D217/20 |
主分类号 |
C07D217/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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