发明名称 |
IMPROVED PROCESS FOR SYNTHESIZING CARBAPENEM INTERMEDIATES |
摘要 |
<p>This invention relates to the synthesis of a bicyclic ketoester compound of the formula 1 obtained by cyclizing a diazo compound of formula 2: in the presence of a rhodium catalyst. <IMAGE> +TR <IMAGE> By adding an effective amount of a Lewis acid to the cyclization reaction, the reaction selectively produces the 1-beta methyl isomer, and epimerization of the 1-beta methyl compound to the 1-alpha isomer is minimized.</p> |
申请公布号 |
GR3036005(T3) |
申请公布日期 |
2001.09.28 |
申请号 |
GR20010400120T |
申请日期 |
2001.06.07 |
申请人 |
MERCK & CO., INC. |
发明人 |
LIU, THOMAS, MENG-HAN;LYNCH, JOSEPH, E.;VOLANTE, RALPH, P. |
分类号 |
C07D477/00;A61K31/397;A61K31/40;A61P31/04;C07D477/04;(IPC1-7):C07D487/00;C07D487/04 |
主分类号 |
C07D477/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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