| 摘要 |
Compounds of formula (I) wherein: N is 0 to 6; R1 is selected from hydrogen, hydroxy, cyano, linear or branched (C1-C6)alkoxy, linear or branched (C1-C6)alkoxycarbonyl, carboxy, aminocarbonyl (the aminomoiety optionally being substituted by one or two identical or different groups selected from linear or branched (C1-C6)alkyl, aryl and aryl(C1-C6)alkyl in which the alkyl moiety may be linear or branched) and NR4R5 wherein R4 and R5, which may be identical or different, selected from linear or branched (C1-C6)alkyl, aryl, aryl(C1-C6)alkyl in which the alkyl moiety may be linear or branched, heteroaryl, heteroaryl(C1-C6)alkyl in which the alkyl moiety may be linear or branched, cycloalkyl, cycloalkyl(C1-C6)alkyl in which the alkyl moiety is linear or branched, linear or branched (C2-C6)alkenyl and linear or branched (C2-C6)alkynyl, R2 represents hydrogen, linear or branched (C1-C6)alkyl, hydroxymethyl, a group of formula (II) wherein: T represents a monocyclic or polycyclic (C3-C12)cyclolkyl group, it being possible for one of the carbon atoms of the cycloalkyl optionally to be replaced by a group selected from O, Se, a group of formula S(O)p wherein p is 0-2, and a group of formula SiR6R7 wherein R6 and R7, which may be identical or different, represent a linear or branched (C1-C6)alkyl group,; U is a bond or methylene group; V is a bond, O or S(O)q wherein q is 0-2, and W is selected from aryl, aryl(C1-C6)alkyl in which the alkyl moiety may be linear or branched, cycloalkyl, and cycloalkyl(C1-C6)alkyl in which the alkyl moiety may be linear or branched; and R3 is selected from hydrogen linear or branched (C1-C6)alkyl, aryl and heteroaryl. The compounds are useful in the treatment of disorders of the central nervous system, such as anxiety, panic attacks, obsessive-compulsive disorders, phobias, impulsive disorders, drug abuse, cognitive disorders, psychoses, depression and mood disorders.
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