NOVEL IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING IRON CHELATORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS

摘要

Use of a compound of formula (I), wherein R<1> is H or hydrocarbyl; R<2> is a hydrophobic radical; R<3> is 3-(C2-C6)acyl-4-hydroxyphenyl, 3-hydroxyimino(C2-C6)-alkyl-4-hydroxyphenyl, or COOZ, wherein Z is H, (C1-C6)alkyl, aryl or ar(C1-C6)alkyl; and n is 1-20; and of a compound of formula (II), wherein R<4> is (C1-C6)acyl, nitro(C1-C6)alkyl, cyano(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl or -CH2NR<7>R<8>, wherein R<7> and R<8>, the same or different, is each H or (C1-C6)alkyl, or together with the N atom form a saturated or unsaturated 5-7 membered ring optionally containing a further heteroatom selected from N, O or S, the further N atom being optionally substituted, and either R<5> is H and R<6> is (C2-C6) acyl or hydroxyimino(C2-C6)alkyl, or R<5> and R<6> together with the phenyl ring form a quinoline, a 1,2,3,4-tetrahydroquinoline or a perhydroquinoline ring, for the preparation of pharmaceutical compositions for the treatment of Parkinson's disease or stroke.