摘要 |
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I) where R<1>, R<2>, n, A, E, X, G and Z have the meanings described in the specification and the claims, as well as optical isomers, diastereomers and enantiomers of Formula I, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.
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申请人 |
THE PROCTER & GAMBLE COMPANY;PIKUL, STANISLAW;OHLER, NORMAN, EUGENE;ALMSTEAD, NEIL, GREGORY;LAUGHLIN, STEVEN, KARL;NATCHUS, MICHAEL, GEORGE;DE, BISWANATH |
发明人 |
PIKUL, STANISLAW;OHLER, NORMAN, EUGENE;ALMSTEAD, NEIL, GREGORY;LAUGHLIN, STEVEN, KARL;NATCHUS, MICHAEL, GEORGE;DE, BISWANATH |