MODIFIED BLOOD CLOTTING FACTORS AND METHODS OF USE
摘要
The invention provides compositions including modified blood clotting factors that have a non-native proteolytic cleavage site engineered into them allowing intracellular cleavage and secretion of an active form. The compositions are useful in the methods for treating a bleeding or clotting disorder.
申请公布号
WO0170763(A1)
申请公布日期
2001.09.27
申请号
WO2001US09355
申请日期
2001.03.22
申请人
THE CHILDREN'S HOSPITAL OF PHILADELPHIA;HIGH, KATHERINE, A.;MARGARITIS, PARIS;CAMIRE, RODNEY, M.
发明人
HIGH, KATHERINE, A.;MARGARITIS, PARIS;CAMIRE, RODNEY, M.
