| 摘要 |
<p>Compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess metalloprotease activity. In particular, the compounds have a structure according to the following Formula (I): where A, G, R?1, R2, R3¿, X, Y and Z have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of Formula I, pharmaceutically-acceptable salts, biohydrolyzable, esters thereof and conjugates thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions. This invention also includes intermediates useful for the synthesis of the compounds of Formula (I).</p> |
