摘要 |
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to Formula (I) where R<1>, R<2>, n, A, E, E', L, L', G and Z have the meanings described in the specification and the claims, as well as optical isomers, diastereomers and enantiomers of Formula (I), and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.
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申请人 |
THE PROCTER & GAMBLE COMPANY;NATCHUS, MICHAEL, GEORGE;PIKUL, STANISLAW;ALMSTEAD, NEIL, GREGORY;LAUFERSWEILER, MATTHEW, J.;BOOKLAND, ROGER, GUNNARD;TULLIS, JOSHUA, S.;DE, BISWANATH |
发明人 |
NATCHUS, MICHAEL, GEORGE;PIKUL, STANISLAW;ALMSTEAD, NEIL, GREGORY;LAUFERSWEILER, MATTHEW, J.;BOOKLAND, ROGER, GUNNARD;TULLIS, JOSHUA, S.;DE, BISWANATH |