USE OF AZITHROMYCIN FOR INFECTIONS WITH LEISHMANIA

摘要

The present invention generally relates to an in vitro analysis of anti-Leishmania activity of the anti-parasitic agent azithromycin, and more particularly the invention uses a novel source of macrophages, which are monocyte-derived bone marrow macrophages, to show the effcicacy of azithromycin anti-parasitic therapy. The figure 1 shows the Multiplication Index for Leishmania major in murine macrophages placed in in vitro culture with 0.1-15 micrograms/ml of azithromycin or 1mg/ml of amphotericin B.