发明名称 |
BRCA-1 REGULATORS AND METHODS OF USE |
摘要 |
The invention provides ribozymes and encoding nucleic acids having target recognition sequences that allow the ribozyme to target and cleave BRCA-1 regulators, resulting in upregulation of BRCA-1 in a cell. Also provided are nucleic acids encoding BRCA-1 regulators that contain the target sequences recognized by the ribozymes of the invention. Fragments of these nucleic aci d and protein sequences also are provided. Further provided is a method for identifying a gene where the expression level is affected by a BRCA-1 regulator and the identity of several such affected genes. Still further provided is a method of identifying a compound that modulates the activity o f a BRCA-1 regulator. Also provided is a method of treating cancer, comprising introducing a ribozyme selectively reactive with an RNA encoding a BRCA-1 regulator into a cancerous cell. The invention further comprises a method of detecting a neoplastic cell in a sample.
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申请公布号 |
CA2402834(A1) |
申请公布日期 |
2001.09.27 |
申请号 |
CA20012402834 |
申请日期 |
2001.03.23 |
申请人 |
IMMUSOL INCORPORATED;BEGER, CARMELA |
发明人 |
WONG-STAAL, FLOSSIE;BARBER, JACK R.;BEGER, CARMELA |
分类号 |
C12N15/09;A61K31/7105;A61K38/00;A61K48/00;A61P35/00;C07K14/47;C12N9/00;C12N15/113;C12N15/12;C12Q1/02;C12Q1/37;C12Q1/48;C12Q1/68;G01N33/574;(IPC1-7):C12N15/12;C12N15/11;G01N33/68;A61K31/713;C12N9/90 |
主分类号 |
C12N15/09 |
代理机构 |
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地址 |
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