Growth factor binding molecules having a plurality of peptide loops attached to a non-peptide organic scaffold, preferably having pseudo-six amino acid peptide loops with four amino acid sidechains. The growth factor binding molecules specifically bind various growth factors and are suitable for treating a subject having tumors or restinosis. In one embodiment a platelet-derived growth factor binding molecule is disclosed that is used to inhibit tumor growth and angiogenesis in solid tumors.
申请公布号
WO0170930(A2)
申请公布日期
2001.09.27
申请号
WO2001US08920
申请日期
2001.03.21
申请人
UNIVERSITY OF SOUTH FLORIDA;SEBTI, SAID, M.;HAMILTON, ANDREW, D.