发明名称 |
HETEROCYCLIC SIDE CHAIN CONTAINING, N-SUBSTITUTED METALLOPROTEASE INHIBITORS |
摘要 |
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to Formula (I): where R<1>, R<2>, R<3>, n, A, E, X, G, G', M and Z have the meanings described in the specification and the claims, as well as optical isomers, diastereomers and enantiomers of Formula I, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.
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申请公布号 |
WO0170691(A1) |
申请公布日期 |
2001.09.27 |
申请号 |
WO2001US08931 |
申请日期 |
2001.03.02 |
申请人 |
THE PROCTER & GAMBLE COMPANY;PIKUL, STANISLAW;OHLER, NORMAN, EUGENE;ALMSTEAD, NEIL, GREGORY;LAUGHLIN, STEVEN, KARL;NATCHUS, MICHAEL, GEORGE;DE, BISWANATH |
发明人 |
PIKUL, STANISLAW;OHLER, NORMAN, EUGENE;ALMSTEAD, NEIL, GREGORY;LAUGHLIN, STEVEN, KARL;NATCHUS, MICHAEL, GEORGE;DE, BISWANATH |
分类号 |
A61K31/35;A61K31/351;A61K31/445;A61K31/4545;A61K31/535;A61K31/5377;A61K31/635;A61P19/00;A61P19/02;A61P29/00;A61P35/00;A61P43/00;C07D211/34;C07D211/66;C07D211/96;C07D309/06;C07D309/08;C07D309/14;C07D401/12;C07D407/12;(IPC1-7):C07D211/34 |
主分类号 |
A61K31/35 |
代理机构 |
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代理人 |
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地址 |
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