发明名称 |
TNF-alpha converting enzyme |
摘要 |
A metalloprotease that converts TNF-alpha from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
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申请公布号 |
US2001024816(A1) |
申请公布日期 |
2001.09.27 |
申请号 |
US20000727169 |
申请日期 |
2000.11.29 |
申请人 |
BLACK ROY A.;RAUCH CHARLES;MARCH CARL J.;CERRETTI DOUGLAS P. |
发明人 |
BLACK ROY A.;RAUCH CHARLES;MARCH CARL J.;CERRETTI DOUGLAS P. |
分类号 |
C07K16/40;C12N9/64;(IPC1-7):C07H21/04;A61K39/395;C12N9/48 |
主分类号 |
C07K16/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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