摘要 |
The present invention relates to a base composition for preparing a substantially surfactant free composition for topical, oral, nasal, anal, ophthalmic, or vaginal application. The base composition comprises sclerotium gum and carrageenan. Formulas containing the base composition of the present invention are stable at a pH of about 3.0 and lower. The base compositions are also compatible with cationic dispersions, i.e., unlike prior compositions, mixtures of the base composition and a cationic dispersion do not result in the formation of aggregates or the separation of water and hydrophobic ingredients in the composition. Another embodiment of the invention is a composition for topical, oral, nasal, anal, ophthalmic, or vaginal application comprising the base composition of the present invention and at least one dispersion comprising suspended particles of a hydrophobic active agent, a hydrophobic adjuvant, or a combination thereof. The composition is substantially free of emulsifying surfactants and the suspended particles have a diameter less than about 500 nm. Preferably, the composition comprises at least one cationic dispersion. According to one preferred embodiment, the composition has a pH of less than about 5, preferably a pH of less than about 4, and more preferably a pH of less than about 3. Yet another embodiment is a method of preparing the composition of the present invention.
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申请人 |
COLLABORATIVE TECHNOLOGIES, INC.;WILLMOTT, JAMES, M.;CRAWFORD, TIMOTHY, K. |
发明人 |
WILLMOTT, JAMES, M.;CRAWFORD, TIMOTHY, K. |