| 摘要 |
Disclosed are compounds of the formula (I) wherein: R2 is hydrogen, alkyl, o r cycloalkyl; R3 is hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, lower alkynyl, lower alkenyl, nitrile, nitro, -COR4, -CO2R4 , - CONR4R5, -CONR4OR5, -SO2NR4R5, -SO2NR4R5, -SO2R4, -SO3R4, formula (II), or - NR4R5; Y is N or CR7; R9 is lower alkyl, haloalkyl, or aryl; X and Z are independently hydrogen, halogen, lower alkyl, lower alkoxy, trifluoromethyl, hydroxy, nitrile, nitro, -NR4R5, -N(O)R4R5, -NR4R5R6W, -SR4, -C(O)R4, -CO2R4 , - CONR4R5, -SO2NR4R5, -SO2R4, -SO3R4, P(O)(OR4)(OR5), -T(CH2)mQR4, - C(O)T(CH2)mQR4, or -NR4C(O)T(CH2)mQR5; m is 1 to 6. These compounds are usef ul for treating cell proliferative disorders, such as cancer, atherosclerosis, and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases. |
