Oral formulations of medicaments

摘要

A formulation suitable for oral treatment with a medicament comprising: a solid masticable portion and one or more reservoir portions encompassed by said masticable portion; the solid masticable portion consisting of a fully edible material, having mechanical properties conducive to promoting mastication, typified by a stiffness measurement (i.e. Young's modulus) in the range of 0.01-5MPa, and compressive strength in the range of 10 to 10,000 mJ; the reservoir portion or portions comprising a releasable unit dose of the medicament in a fluid (preferably a liquid) form, with a viscosity below 800mPa.s at body temperature (ca. 36-ca.40 DEG C), and preferably between the range of 50-200mPa.s; such that on mastication, the masticable portion is ruptured and the unit dose of the medicament is released in a short space of time from the reservoir portion into the oral cavity.