| 摘要 |
The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof: <CHEM> wherein: R1 represents a hydrogen atom or a C1-6 alkyl group; R2 represents a furan ring, thiophene ring, pyrrole ring or imidazole ring, the rings being optionally substituted by 1 to 3 substituents selected from a C1-6 alkyl group, a halogen atom, a C1-2 perhalogenated alkyl group, a C1-3 halogenated alkyl group, a hydroxyl group, a C1-6 alkoxy group, a nitro, a cyano an amino, a C1-6 monoalkylamino group, a C2-10 dialkylamino group, a C1-6 alkylcarbonylamino group, a C6,10 arylcarbonylamino group or a phenyl group; R3 represents a 2, 3 or 4-pyridyl group optionally substituted by a C1-4 alkyl, group, C1-4 alkoxy group or a halogen atom; n represents 1 to 5. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3 beta such as Alzheimer's disease, Parkinson's disease, frontoparietal dementia, corticobasal degeneration, Pick's disease, cerebrovascular accidents, brain and spinal trauma, and peripheral neuropathies. |
