发明名称 |
Compositions and methods based upon an isoform of p53 |
摘要 |
The present invention is directed to an isoform of the p53 tumor suppressor and to polynucleotides that encode this isoform. The isoform may be used as a marker to indicate that cardiac cells have experienced hypoxia, as would occur during a myocardial infarction. In addition, vectors encoding the isoform may be transfected into cells as a means of regulating proliferation.
|
申请公布号 |
US6294384(B1) |
申请公布日期 |
2001.09.25 |
申请号 |
US19990414436 |
申请日期 |
1999.10.07 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL INC. |
发明人 |
DELL'ACQUA GIORGIO;MANN MICHAEL J.;DZAU VICTOR J. |
分类号 |
A61K38/00;A61K48/00;C07K14/47;C12N15/12;(IPC1-7):C12N15/63 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|