发明名称 |
Method of producing morphologically uniform microcapsules and microcapsules produced by this method |
摘要 |
The invention relates to a process for the production of morphologically uniform microcapsules that contain peptides, proteins or other water-soluble biologically active substances as active ingredients as well as microcapsules that are produced according to this process with a degree of concentration of between 3 to 30% by weight and a diameter<=8 mum.According to the invention, biodegradable polymers are dissolved in a halogen-free solvent or solvent mixture, and the buffered active ingredient solution, which has a pH of between 6.0 to 8.0, is dispersed into this solution. Then, an aqueous solution that contains a surface-active substance (W/O/W-emulsion) is added to this W/O-emulsion, and the solvent is removed.The microcapsules that are produced with this process do not show any tendency toward agglomeration. The encapsulation efficiency of the process is approximately 90 to 95%.
|
申请公布号 |
US6294204(B1) |
申请公布日期 |
2001.09.25 |
申请号 |
US19980068471 |
申请日期 |
1998.09.25 |
申请人 |
INHALE THERAPEUTIC SYSTEMS, INC. |
发明人 |
ROESSLING GEORG;ALBAYRAK CELAL;TACK JOHANNES;SCHMITZ REINHARD |
分类号 |
A61K9/16;A61K9/50;A61K38/00;A61K38/04;A61K38/09;A61K38/21;A61K38/28;A61K38/38;B01J13/02;(IPC1-7):A61K9/48;A61K9/14;A01N37/18 |
主分类号 |
A61K9/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|