发明名称 |
CD123+ dendritic cells in blood and lymphoid tissues |
摘要 |
Dendritic cells (DCs) are the primary antigen presenting cells during the initiation of T cell-dependent immune responses. The cells originate from the bone marrow and have been suggested to represent a distinct cell lineage. However, distinct DC precursors have not been identified in bone marrow, and mature monocytes can also give rise to DCs. The instant invention presents a distinct DC precursor among bone marrow CD34+ cells. The cells express high levels of the interleukin-3 receptor alpha chain and CD4 and can be uniquely identified also in blood and lymphoid tissues by this phenotype.
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申请公布号 |
US6294381(B1) |
申请公布日期 |
2001.09.25 |
申请号 |
US19990391946 |
申请日期 |
1999.09.08 |
申请人 |
OLWEUS JOHANNA;LUND-JOHANSEN FRIDTJOF |
发明人 |
OLWEUS JOHANNA;LUND-JOHANSEN FRIDTJOF |
分类号 |
C07K16/28;C12N5/0784;G01N33/569;(IPC1-7):C12N5/06;C12N5/08;G01N33/53;G01N33/536 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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