摘要 |
<p>Nitric oxide-specific electrodes are useful for in situ detection of nitric oxide in biomedical applications and have at least a surface region thereof which is capable of forming complexes with nitric oxide, for example, nitrosyl complexes, or any structural isomers thereof. The nitric oxide complexes formed at the surface of the electrodes apparently increase the concentration of nitric oxide available for detection, thereby leading to significantly improved relative responses as compared to other known nitric oxide electrode materials. Most preferably, the electrode has at least an exterior surface region which contains ruthenium and/or at least one oxide of ruthenium. The electrodes are advantageously preconditioned at a pre-conditioning potential, or potentials, different than the working potential of the electrode, followed by further conditioning at the working potential. Direct response of the electrodes to nitric oxide has been observed for ruthenium electrodes at or below potentials about +675 mV vs. Ag/AgCl, while a paradoxical response of the electrodes to nitric oxide has been observed for ruthenium electrodes at potentials above +675 mV vs. Ag/Cl.</p> |