PRODUCTS AND METHODS FOR ACTIVATING PPAR gamma -RXR AND UP-REGULATING MONOCYTE/MACROPHAGE CD36 FOR THE TREATMENT OF MALARIA

摘要

This invention relates to therapeutic products to treat Plasmodium falciparum malaria. According to a first aspect of the invention, a composition for the treatment of malaria is disclosed. The composition includes, as an active ingredient, a PPAR gamma and/or a RXR agonist which upregulates monocyte/m phi CD36 in admixture with a pharmaceutically acceptable carrier, excipient or diluent. According to second aspect of the invention, a method of treating or preventing severe infection by P. falciparum in a person is provided. The method includes the steps of: (a) forming a composition by combining a PPAR gamma and or a RXR agonist with an acceptable carrier, excipient or diluent; and (b) administering an effective dose of the composition to a person infected with or at risk of infection with P. falciparum.