| 发明名称 |
COMPOUNDS CAPABLE OF BINDING WITH PROTEINS CONSTITUTING OR ASSOCIATED WITH THE CYTOSKELETON ELEMENTS AND THEIR USES FOR PRODUCING MEDICINES |
| 摘要 |
The invention concerns the use of steroids and non-toxic compounds, capable of crossing the blood brain barrier characterised in that they are capable of binding the same site as pregnenolone on proteins constituting or associated with elements of the cytoskeleton and of displacing the MAP2-bound pregnenolone, and of influencing the assembling and stabilisation of microtubules. The invention is particularly useful for treating the nervous system, for fighting against ageing of cells containing MAPs, and for treating cancers.
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| 申请公布号 |
WO0168068(A2) |
申请公布日期 |
2001.09.20 |
| 申请号 |
WO2001FR00816 |
申请日期 |
2001.03.19 |
| 申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (I.N.S.E.R.M.);BAULIEU, ETIENNE-EMILE;ROBEL, PAUL;FELLOUS, ESTHER;MURAKAMI, KOICHI |
发明人 |
BAULIEU, ETIENNE-EMILE;ROBEL, PAUL;FELLOUS, ESTHER;MURAKAMI, KOICHI |
| 分类号 |
A61K31/00;A61K31/57;A61K38/00;A61P5/00;A61P25/00;A61P25/28;A61P35/00;A61P43/00;(IPC1-7):A61K31/00 |
主分类号 |
A61K31/00 |
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