| 摘要 |
<p>Novel cells expressing phenylalanine hydroxylase activity and novel fusion proteins comprising, in addition to the phenylalanine hydroxylase activity, a polypeptide enhancing and/or stabilising the phenylalanine hydroxylase activity are provided. The cells are useful for treatment of phenylketonuria (PKU) that is caused by genetically conditioned metabolic disorders in humans and animals resulting in an accumulation in the body of phenylalanine. The cells and/or proteins may be administered directly to the PKU patients to effect conversion of phenylalanine in the body, or added to proteinaceous food products in order to reduce the content of phenylalanine.</p> |
