摘要 |
O-Carbamyl-D-serine is produced by cultivating the organism Streptomyces orchidaceous in an aqueous nutrient cultivation medium, adjusting the pH of the medium to from 2 to 5, passing the medium through a cation-exchange resin to adsorb cycloserine, adjusting the pH of the effluent to from 4 to 6.5, concentrating the effluent and cooling the concentrated effluent at a temperature and for a time sufficient to crystallize O-carbamyl-D-serine from the effluent. This process is generally applicable to the recovery of O-carbamyl-D-serine when in admixture with cycloserine in an aqueous solution. Reference has been directed by the Comptroller to Specification 775,946.
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