摘要 |
A coformulation of an active (preferably pharmaceutically active, for instance a COX-2 enzyme inhibitor) substance and an oligomeric or polymeric excipient, containing at least 10 % of the active, between 80 and 100 % of which is amorphous. The amorphous phase is stable, with respect to the crystalline phase(s), for at least theree months after its preparation when stored at between O and 10 DEG C. The invention also provides processes, preferably involving SEDS<TM> particle formation, for preparing such a coformulation.
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申请人 |
BRADFORD PARTICLE DESIGN PLC;BRISTOL-MYERS SQUIBB COMPANY;YORK, PETER;WILKINS, SIMON, ANTHONY;STOREY, RICHARD, ANTHONY;WALKER, STEPHEN, ERNEST;HARLAND, RONALD, SCOTT |
发明人 |
YORK, PETER;WILKINS, SIMON, ANTHONY;STOREY, RICHARD, ANTHONY;WALKER, STEPHEN, ERNEST;HARLAND, RONALD, SCOTT |