发明名称 |
OPIOID FORMULATIONS |
摘要 |
The present invention provides high-concentration formulations of opioids such as fentanyl or fentanyl congeners. The formulation of the invention comprises fentanyl or a fentanyl congener in concentrations significantly in excess of conventional formulations, e.g., on the order about 2-fold to about 10,000-fold greater than conventional formulations, e.g., currently commercially available formulations. These formulations are particularly useful for long-term delivery to a subject suffering from pain. The invention further provides drug delivery devices comprising the high-concentration opioid formulations, and further provides methods of alleviating pain in a subject, comprising administering the high-concentration formulations to a subject in need thereof.
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申请公布号 |
WO0168140(A2) |
申请公布日期 |
2001.09.20 |
申请号 |
WO2001US06955 |
申请日期 |
2001.03.02 |
申请人 |
DURECT CORPORATION;LITMANOVITZ, DANA;LAIDLAW, BARBARA, J., F. |
发明人 |
LITMANOVITZ, DANA;LAIDLAW, BARBARA, J., F. |
分类号 |
C07D211/58;A61K9/00;A61K31/4468;A61K31/4515;A61K31/4535;A61K47/10;A61K47/14;A61K47/26;A61K47/34;A61P25/02;A61P25/04;A61P29/00;C07D409/06;(IPC1-7):A61K47/26;A61K31/446 |
主分类号 |
C07D211/58 |
代理机构 |
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