发明名称 |
CHIMERIC ANIMAL MODEL SUSCEPTIBLE TO HUMAN HEPATITIS C VIRUS INFECTION |
摘要 |
The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunicompromised xenogeneic transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-tape plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. |
申请公布号 |
CA2402117(A1) |
申请公布日期 |
2001.09.20 |
申请号 |
CA20012402117 |
申请日期 |
2001.03.16 |
申请人 |
TYRRELL, D. LORNE;MERCER, DAVID F.;KNETEMAN, NORMAN M. |
发明人 |
TYRRELL, D. LORNE;MERCER, DAVID F.;KNETEMAN, NORMAN M. |
分类号 |
A01K67/027;C07K14/765;C12N7/02;C12N9/64;C12N15/63;C12N15/85;C12R1/93;G01N33/15;G01N33/48;G01N33/50;(IPC1-7):A01K67/027;A61K49/00;C12N7/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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