THREE-DIMENSIONAL MODEL OF A FC REGION OF AN IGE ANTIBODY AND USES THEREOF

摘要

The present invention includes three-dimensional models of antibodies, such as Fc-C.epsilon.3/C.epsilon.4 regions of IgE antibodies, as well as methods to produce such models. The present invention also includes muteins having increased stabiltiy and/or antibody receptor binding activity, as well as methods to produce such muteins, preferably using information derived from three-dimensional models of the present invention. Also included are nucleic acid sequences encoding muteins of the present invention and use of those sequences to produce such muteins. Also included is the use of themodel to identify compounds that inhibit the binding of an antibody receptor protein to an antibody. The present invention also includes uses of such muteins and inhibitory compounds, for example, in methods to diagnose and protect animal s from allergy and othter abnormal immune responses.