发明名称 |
CAPSID FORMING AND CYSTEIN MODIFIED CHIMAERIC MS2-COAT PROTEIN |
摘要 |
PCT No. PCT/GB92/01159 Sec. 371 Date Jan. 3, 1995 Sec. 102(e) Date Jan. 3, 1995 PCT Filed Jun. 26, 1992 PCT Pub. No. WO93/00434 PCT Pub. Date Jan. 7, 1993A chimaeric protein is provided, capable of forming part of a capsid assembly and comprising the amino acid sequence of the coat protein of phage MS-2, or a conservatively modified variant thereof, or sufficient of said sequence or variant to retain the capability of forming a capsid assembly, which amino acid sequence has been modified by removal of the cysteine residues present externally of the N-terminal protruberant beta -hairpin of the coat protein and insertion of a cysteine residue within the region corresponding to the N-terminal protruberant beta -hairpin. |
申请公布号 |
EP0591369(B1) |
申请公布日期 |
2001.09.19 |
申请号 |
EP19920913894 |
申请日期 |
1992.06.26 |
申请人 |
BTG INTERNATIONAL LIMITED |
发明人 |
MASTICO, ROBERT, ALLAN;STOCKLEY, PETER GEORGE |
分类号 |
A61K39/385;A61K39/00;A61K47/48;C07K14/00;C07K14/005;C07K14/08;C07K14/11;C07K14/705;C07K19/00;C12N15/09;C12N15/33;C12N15/34;C12N15/44;C12P21/02;C12R1/19;C12R1/92 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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