发明名称 |
ARTERY- AND VEIN-SPECIFIC PROTEINS AND USES THEREFOR |
摘要 |
Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous endothelial cells are necessary for angiogenesis. |
申请公布号 |
EP1133310(A2) |
申请公布日期 |
2001.09.19 |
申请号 |
EP19990919828 |
申请日期 |
1999.04.13 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
WANG, HAI, U.;CHEN, ZHOUFENG;ANDERSON, DAVID, J. |
分类号 |
A01K67/027;A61K38/17;A01K67/00;A01K67/033;A61K35/12;A61K38/00;A61K38/19;A61K39/00;A61K39/395;A61K45/00;A61K47/46;A61K47/48;A61K49/00;A61P9/00;A61P9/10;A61P35/00;C07H21/04;C07K14/00;C07K14/705;C07K16/00;C07K16/28;C12N5/00;C12N5/02;C12N5/071;C12N5/10;C12N15/09;C12N15/85;C12P21/02;C12Q1/04;C12Q1/68;G01N33/48;G01N33/50;G01N33/53;G01N33/567;G01N33/574;(IPC1-7):A61K38/17;C12N5/06;C12N5/08 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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