发明名称 |
Alteration of the cell cycle in vivo, and particularly for inducing apoptosis of tumor cells |
摘要 |
A first substance (such as the peptide aldehydes LLnL and LVP) inhibits the function of intracellular proteasome. A second substance (such as ranpirnase) inhibits intracellular protein synthesis or increases intracellular expression of a cyclin-dependent kinase (CDK) inhibitor. Both substances are administered in such a manner that the effects thereof are coincident. The cell cycle of affected tumor cells is therefore arrested and the cells die of apoptosis.
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申请公布号 |
US6290951(B1) |
申请公布日期 |
2001.09.18 |
申请号 |
US19980127619 |
申请日期 |
1998.08.01 |
申请人 |
ALFACELL CORPORATION |
发明人 |
MIKULSKI STANISLAW M. |
分类号 |
C12N5/06;A61K38/00;A61K38/46;A61K45/06;A61P35/00;(IPC1-7):C12N5/00 |
主分类号 |
C12N5/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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