发明名称 |
Solid supported synthesis of hydroxamic acids |
摘要 |
The subject invention involves processes for making hydroxamic acid compounds using a solid-support resin having an oxime moiety as the linking moiety of the resin, comprising the steps of (a) treating the resin with a carboxylic acid compound, such that it is attached to the resin by a condensation reaction between the oxime and carboxyl moieties; (b) optionally modifying the side chain; (c) cleaving a product from the resin by treating with O-tert-butyldimethylsilylhydroxylamine; (d) optionally modifying the side chain; and (e) optionally treating the resulting O-TBS-protected material with acid to produce an unprotected hydroxamic acid compound.
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申请公布号 |
US6291709(B1) |
申请公布日期 |
2001.09.18 |
申请号 |
US20000582975 |
申请日期 |
2000.07.07 |
申请人 |
THE PROCTER & GAMBLE COMPANY |
发明人 |
GOLEBIOWSKI ADAM;KLOPFENSTEIN SEAN REES |
分类号 |
C07B61/00;C07C259/04;(IPC1-7):C07C259/04 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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