Nucleic acids containing modified human immunodeficiency virus genomes devoid of long terminal repeats encoding non-infectious, replication-deficient, immunogenic retrovirus-like particles

摘要

An immunogenic retrovirus-like particle which is non-infectious and non-replicating and which is useful as a candidate vaccine component against retroviral infections, including AIDS and ATLL, is produced by genetic engineering. A DNA molecule comprising a retroviral genome devoid of long terminal repeats is incorporated into an expression vector, which is introduced into mammalian cells for expression of the retrovirus-like particle.