发明名称 |
QUINOLINE AND QUINAZOLINE COMPOUNDS USEFUL IN THERAPY |
摘要 |
The invention provides compounds of formula (I), wherein R1 represents C1-4 alkoxy optionally substituted by one or more fluorine atoms; R2 represents H or C1-6 alkoxy optionally substituted by one or more fluorine atoms; R3 represents one or more groups independently selected from H, halogen, C1-4 alkoxy and CF3; in addition, R2 and one R3 group may together represent -OCH 2- , the methylene group being attached to the ortho-position of the pendant phenyl ring; R4 represents a 4-, 5- or 6-membered heterocyclic ring containi ng 1 or 2 heteroatoms selected from N, O and S, the ring being optionally fused to a benzene ring or a 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms selected from N, O and S, the ring system as a whole being optionally substituted; X represents CH or N; and L is absent or represents a cyclic group or an open chain group; and pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful in the treatment of inter alia benign prostatic hyperplasia.
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申请公布号 |
CA2236814(C) |
申请公布日期 |
2001.09.18 |
申请号 |
CA19962236814 |
申请日期 |
1996.12.05 |
申请人 |
PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. |
发明人 |
FOX, DAVID NATHAN ABRAHAM;NEWMAN, JULIE;COLLIS, ALAN JOHN |
分类号 |
A61K31/47;A61K31/495;A61K31/496;A61K31/505;A61K31/517;A61K31/535;A61K31/5355;A61K31/55;A61P7/00;A61P9/06;A61P9/12;A61P13/02;A61P15/00;C07D215/42;C07D239/94;C07D239/95;C07D401/04;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D403/14;C07D405/12;C07D405/14;C07D471/04;C07D491/04;C07D491/048;C07D491/052;C07D497/04;C07D513/04;(IPC1-7):C07D401/04;C07D243/08;A61K31/54 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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