| 摘要 |
<p>PURPOSE: Provided are cephalosporin derivatives of the formula(1), and their manufacturing method and use as pharmaceutically active substances, particularly for the treatment and prophylaxis of infectious diseases. CONSTITUTION: A cephalosporin derivative is represented by the formula(1), wherein X is CH or N; R¬1 is hydrogen or cyclopentyl; R¬2 is selected from the group consisting of formulae; R¬3 is hydrogen, an alkalimetal ion or a tertiary ammonium group; R¬4 is hydrogen, an amino protecting group, pyrrolidin-2-ylmethyl, azetidin-3-ylmethyl, iminomethyl, or 1-carbamimidoyl; R¬5 is hydrogen, dialkylcarbamoyl, .omega.-hydroxyalkyl, .omega.-aminoalkyl, 1-hydroxy-3-aminomethyl-propyl or (hydroxy)-(pyrrolidin-2-yl)methyl; R¬6 is hydrogen, trifluoromethyl or hydroxy; and R¬7 is alkyl, .omega.-hydroxy-alkyl, cycloalkyl, 3-pyrrolidinyl, 3-azetidinyl, iminomethyl or 1-carbamimidoyl.</p> |
