| 摘要 |
The invention provides methods of protecting solid-state proteins from t he effects of ionizing radiation which comprise combining the protein with a radiation- protecting amount of a methoxysalicylaldehyde derivative, preferably 3- methoxysalicylaldehyde; radiation-protecting amounts of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde, and 6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxylic acid; or radiation-protecting amounts of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde and isopropanol, prior to exposing the protein to ionizing radiation. The invention further provides radiation-resistant pharmaceutical formulatio ns comprising a protein and a methoxysalicylaldehyde derivative, preferably 3- methoxysalicylaldehyde; a protein and a combination of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde, and 6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxylic acid; or a protein and a combination of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde and isopropanol. The invention still further provides a composition comprising a combination of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde, an d 6- hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, and for the use of suc h composition in pharmaceutical formulations as a radioprotectant.
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