RECOMBINANT NUCLEIC ACID MOLECULE CAPABLE OF ENCODING INTERCELLULAR ADHESION MOLECULE 3, FUNCTIONAL DERIVATIVES OF ICAM-3 AND PHARMACEUTICAL COMPOSITIONS CONTAINING ICAM-3 OR FUNCTIONAL DERIVATIVES THEREOF

摘要

The present invention relates to intercellular adhesion molecules (ICAM-3) which is involved in the process through which leukocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes therapeutic and diagnostic uses for adhesion molecules and for the antibodies that are capable of binding them.