Novel vectors which are replication-competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to neoplastic cells or to neoplastic alveolar type II cells. Compositions and methods for promoting the death of neoplastic cells using these replication-competent vectors are also disclosed.
申请公布号
WO0104282(A3)
申请公布日期
2001.09.13
申请号
WO2000US18971
申请日期
2000.07.12
申请人
SAINT LOUIS UNIVERSITY;WOLD, WILLIAM S., M.;TOTH, KAROLY;DORONIN, KONSTANTIN;TOLLEFSON, ANN, E.
发明人
WOLD, WILLIAM S., M.;TOTH, KAROLY;DORONIN, KONSTANTIN;TOLLEFSON, ANN, E.