发明名称 |
Multi-partite ligands and methods of identifying and using same |
摘要 |
The invention provides methods for generating a library of bi-ligands, comprising (a) determining a common ligand to a conserved site in a receptor family; (b) attaching an expansion linker to the common ligand, wherein the expansion linker has sufficient length and orientation to direct a second ligand to a specificity site of a receptor in the receptor family, to form a module; and (c) generating a population of bi-ligands comprising a plurality of identical modules attached to variable second ligands. The invention also provides methods for identifying a bi-target ligand to a receptor by combining a first bi-ligand to a first receptor in a receptor family and a second bi-ligand to a second receptor in the receptor family. The invention additionally provides bi-ligands and bi-target ligands.
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申请公布号 |
US2001021533(A1) |
申请公布日期 |
2001.09.13 |
申请号 |
US20010765693 |
申请日期 |
2001.01.19 |
申请人 |
TRIAD BIOTECHNOLOGY, INC. |
发明人 |
SEM DANIEL S. |
分类号 |
G01N33/50;A61K51/00;C07B61/00;C07G99/00;C12Q1/00;C12Q1/02;C12Q1/25;G01N33/53;G01N33/542;G01N33/566;(IPC1-7):G01N33/543 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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