发明名称 |
Mucosally targeted immunization |
摘要 |
The invention concerns the use of an immunogen specific of a pathogenic agent with a gateway in the buccal mucous membrane region, for producing a vaccine composition to be administered in the floor of the mouth in a human being so as to develop directly a local response in IgA antibodies and in B cells secreting IgA in the buccal mucous membrane, saliva and ganglions draining said mucous membrane. The invention also concerns a vaccine composition capable of being applied in the floor of the mouth in a human being to induce local and systemic immunity in IgA antibodies, substantially consisting of a material adhering or not to the buccal mucous membrane and containing an immunogen specific of the pathogenic agent with a gateway into the buccal mucous membrane.
|
申请公布号 |
US2001021384(A1) |
申请公布日期 |
2001.09.13 |
申请号 |
US20000746581 |
申请日期 |
2000.12.21 |
申请人 |
JOURDIER THERESE;MOSTE CATHERINE;MEIGNIER BERNARD |
发明人 |
JOURDIER THERESE;MOSTE CATHERINE;MEIGNIER BERNARD |
分类号 |
A61K9/00;A61K9/16;A61K9/50;A61K39/12;A61K39/21;A61K48/00;C07K14/16;(IPC1-7):A61K39/00;A61K39/38;A61K39/09;A61K39/10 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|